搜索结果: 1-14 共查到“基础医学 eosinophils”相关记录14条 . 查询时间(0.061 秒)
Activation of Eosinophils by Lipopolysaccharide-Induced Monocyte-Derived Cytokines
allergy chronic lung disease eosinophils lipopolysaccharide (LPS) monocytes
2010/11/16
Background: Interactions between eosinophils and monocytes after lipopolysaccharide inhalation are yet to be investigated. The mechanism of eosinophil activation induced by lipopolysaccharide in the p...
House Dust Mite Extract Induces Interleukin-9 Expression in Human Eosinophils
allergens eosinophils house dust mites interleukin-9 proteinase activated receptor 2
2010/11/17
Accumulated eosinophils in the airways in asthma may directly react with HDM and produce IL-9 to further promote Th2-type immune responses. Protease-activated receptor 2, a ligand for serine proteases...
Serum Concentrations of Eosinophil Cationic Protein and Eosinophils of Patients with Kimura's Disease
EG-2 eosinophil cationic protein eosinophils Kimura's disease
2010/11/18
Background: To clarify the role of eosinophils in the pathogenesis of Kimura's disease and the values of measuring serum levels of eosinophil cationic protein (ECP) for monitoring disease activity mig...
Reduction of Eosinophils in Small Airways by Inhaled Steroids is Insufficient in Patients with Adult Asthma
bronchial asthma eosinophil inhaled corticosteroid small airways treatment
2010/11/19
Background: Recent reports suggest that small airway as well as large airway involvement in asthma is important. We investigate the therapeutic effects of a meter-dose inhaler of chrolofluorocarbon-be...
Inhibitory effects of pemirolast potassium and FK506 on degranulation and IL-8 production of eosinophils
anti-allergic drug cytokine eosinophil degranulation
2010/11/26
Eosinophils are the key effector cells for allergic inflammation. In order to clarify drugs which can regulate eosinophil function, we investigated the direct effect of pemirolast potassium (anti-alle...
β2 Integrin-dependent tyrosine phosphorylation of proline-rich tyrosine kinase 2 in platelet-activating factor-activated eosinophils
degranulation eosinophil β2 integrin PYK-2 tyrosine phosphorylation
2010/11/26
Platelet-activating factor (PAF) can activate various cellular functions, including degranulation in eosinophils. In the present study, we examined tyrosine phosphorylation of intracellular proteins i...
Eotaxin-induced expression of membrane type 1 matrix metalloproteinase mRNA in human eosinophils
basement membrane degradation eosinophil eotaxin matrix metalloproteinase-2 matrix metalloproteinase-9 membrane-type matrix metalloproteinase
2010/11/25
Eosinophil penetration across the basement membrane (BM) is thought to be dependent on the degradation of membrane components. In this process, matrix metalloproteinases (MMP) appear to be primarily r...
Direct flowcytometric analysis of eosinophils using a whole blood staining technique
EG2 eosinophils flow cytometry whole blood
2010/11/25
The findings show that intra- and extracellular properties of eosinophils can be analyzed with whole blood using PBQ fixation and OG treatment at a concentration of 7.4 mg/mL. Direct flowcytometric an...
Inhibitory effect of olopatadine hydrochloride (KW-4679), a novel antiallergic drug, on peptide leukotriene release from human eosinophils
antiallergic drug human eosinophils leukotriene olopatadine
2010/11/25
Olopatadine hydrochloride (olopatadine; KW-4679), (Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride, is an antiallergic drug with selective and potent...
Effects of Th2 cytokines and eosinophils on stem cell factor production by lung fibroblasts
eosinophil fibroblast interleukin-4 interleukin-5 stem cell factor
2010/11/24
Interleukin-4 significantly enhanced SCF production, whereas tumor necrosis factor-α, interferon-γ and IL-1α showed suppressive effects on SCF pro-duction. When fibroblasts were cultured with IL-4 plu...
Inhibition of nasal mucosal eosinophils after immunotherapy is associated with a decrease in interleukin-13 mRNA and vascular cell adhesion molecule-1 expression
adhesion molecule allergic rhinitis apoptosis immunotherapy interleukin-13
2010/11/22
Analysis of the clinical data confirmed that the proportion of patients who showed greater than 60% improvement in symptoms (47 and 15%) and in rescue medication (79 and 10%) were significant for the ...
Prostaglandin D2 and interleukin-5 reduce CRTH2 surface expression on human eosinophils
CRTH2 eosinophils interferon-γ interleukin-4 interleukin-5 prostaglandin D2
2010/11/22
Background: Recently, a second prostaglandin D2 (PGD2) receptor, chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), was identified. Because PGD2 was reported to have chemotac...
Comparison of local cytokine gene expression and the distribution of eosinophils and CD4-positive cell subsets in the paranasal sinus mucosa between atopic and non-atopic subjects
allergic rhinitis CCR4 CD4 chronic sinusitis CXCR3 cytokines eosinophils
2010/11/22
These results indicate that high expression of Th2-type cytokines concomitant with the infiltration of a predominant number of CD4+ cells and their Th2 subsets play a role in the pathogenesis of eosin...
Differential effects of corticosteroids and theophylline on the adhesive interaction between eosinophils and endothelial cells
cell adhesion corticosteroids endothelial cells eosinophils theophyline
2010/11/22
Corticosteroids and theophylline have been used widely for the treatment of asthma. These two classes of drugs appear to reduce the tissue infiltration of eosinophils, predominant inflammatory cells i...