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Production of Recombinant Alpha Neurotoxin of Scorpion Venom Mesobuthus eupeus and Analysis of its Immunogenicity
Venoms Neurotoxin Scorpion Recombinant Protein
2015/10/10
Background:: Scorpion venom is important and rich source of peptides, most of which have been widely used as pharmacological tools for unraveling structure-function relationship of various ion channel...
Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production
vitamin C cyclooxygenase-2 oxidative stress Alzheimer’s disease stroke reactive oxygen species neuroinflammation NSAIDs 8-isoprostanes prostaglandin E synthase
2015/8/3
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathop...
Production and Purification of Monoclonal Antibodies to Human Interleukin-2 and Their Use for Immunoaffinity Purification of Recombinant Human Interleukin-2
Monoclonal antibody human interleukin-2 immunoaffinity purification
2009/6/26
Monoclonal antibodies (mAbs) are a powerful immunochemical tool. Today, the availability of mAbs with desired specificity enables ligand separation based upon the immunoaffinity technique. By using th...
Gamma-globulin Inhibits Superantigen-induced Lymphocyte Proliferation and Cytokine Production
neutralizing antibody pooled human immunoglobulin Staphylococcal enterotoxin B superantigen
2010/11/18
Background: High-dose pooled human immunoglobulin (PHIG) treatment is sometimes effective in superantigen related inflammatory diseases, such as toxic shock syndrome and Kawasaki disease. Neutralizing...
Lactobacillus Acidophilus Strain L-92 Regulates the Production of Th1 Cytokine as well as Th2 Cytokines
Lactobacillus acidophilus strain L-92 Peyer's patch splenocytes TGF-β Treg
2010/11/18
Oral L-92 administration regulated both Th1 and Th2 cytokine responses, suppressed serum OVA-specific IgE, and induced TGF-β production in PPs. TGF-β is known to be associated with activation of regul...
Production of Matrix Metalloproteinases in Human Cultured Mast Cells: Involvement of Protein Kinase C—Mitogen Activated Protein Kinase Kinase—Extracellular Signal-regulated Kinase Pathway
human cultured mast cells matrix metalloproteinase-9 membrane type matrix metalloproteinase tissue inhibitor of metalloproteinase-1 tissue inhibitor of metalloproteinase-2
2010/11/18
We detected the de novo synthesis of MMP-9 in HCMC after stimulation with PMA and found that the synthesis was mediated through protein kinase C—mitogen activated protein kinase kinase (MEK)—ERK pathw...
Inhalant corticosteroids inhibit mechanical strain-induced RANTES and eotaxin production by human airway smooth muscle cells
airway smooth muscle cells eotaxin inhaled corticosteroids mechanical strain RANTES
2010/11/24
The results showed that: (i) mechanical strain, including stretch and compression, stimulated ASM cells to produce RANTES and eotaxin; and (ii) FP and BUD inhibited mechanical strain-induced and TNF-α...
Positional Effect of Amino Acid Replacement on Peptide Antigens for the Increased IFN-γ Production from CD4T Cells
analogue peptide complementarity determining region 3 interferon gamma peptide antigens T-cell antigen receptor
2010/11/19
Background: Based on the fact that site-specific amino acid replacement on peptide antigens stimulated T cell clones to produce increased amount of IFN-γ, we investigated this structure-function relat...
Anti-Cryptococcal-Globulin-Latex Production for Rapid Detection of Cryptococcus neoformans Polysaccharide Antigen in Cryptococcosis
Antigen detection Anticryptococcal globulin Latex agglutination Cryptococcosis
2010/2/5
Cryptococcosis has become the fourth leading life-threatening opportunistic infection in patients with AIDS, but also occurs in non-AIDS patients. In view of the increasing numbers of infection during...