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广州健康院在高选择性BET BD2抑制剂用于治疗AML的研究中获新进展（图）
治疗 抑制剂 临床试验
2024/1/17
2024年1月16日，中国科学院广州生物医药与健康研究院许永团队与中国药科大学吴筱星团队合作，报道了一系列苯氧芳基吡啶酮作为高选择性BET BD2抑制剂用于AML的治疗。相关成果以“Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with ...
急性髓系白血病（Acute Myeloid Leukemia，AML）是造血系统的髓系原始祖细胞恶性增殖性疾病。据美国癌症协会估计，2022年美国急性髓系白血病的发病病例约20050例，死亡病例约11540例。尽管AML的发病机制研究和临床前研究取得了显著进展，但AML患者的5年生存率仍然很差（< 40%）。因此，临床上急需开展基于新靶点、新机制的抗AML药物研究。
探讨抑制性寡脱氧核苷酸（suppressive oligodeoxynucleotide，Sup ODN）对刀豆蛋白A（ConA）诱导肝损伤小鼠兔抗鼠磷酸化信号转导和转录激动子4抗体 (pSTAT4) 、pSTAT6和Tbet表达的影响及其意义。方法Balb/C小鼠40只被随机分为4组，分别为生理盐水（NS，空白对照）组、环孢菌素A（CsA）组（阳性对照）、Con ODN组（对照ODN）、Sup...
目的: 探讨哮喘患者PBMCs中转录因子T-bet/GATA-3比率与Th1/Th2细胞失衡的关系及体外CpG干预后T-bet/GATA3比率的变化及其对Th1/Th2细胞平衡的调节作用。方法: 用RT-PCR法测定30例发作期哮喘患者（哮喘组）及20例慢性阻塞性肺病患者（COPD组）及20例正常人（对照组） PBMCs中T-bet mRNA、GATA-3 mRNA及TLR9 mRNA的表达强度，...
Detection of Specific IgE Antibodies in Sera of Japanese Birch-Allergic Patients Using Recombinant Allergens Bet v 1, Bet v 2 and Bet v 4
Bet v 1 Bet v 2 birch pollinosis RAST
2010/11/17
Background: Birch pollen is the major allergen in pollinosis in northern Japan. IgE reactivity to individual birch pollen allergens has been shown to differ between populations of birch pollen-allergi...
Measurement of IgE and IgG4 antibodies against purified grass pollen allergens (Phl p 1, Phl p 2, Phl p 5 and Bet v 2) and natural extracts after short-term grass immunotherapy
grass pollen allergy IgE IgG4 immunotherapy olive pollen recombinant allergens
2010/11/25
We wanted to define allergen-specific antibodies that change due to specific immunotherapy. We conducted a study with grass pollen-allergic patients and compared allergen-specific IgE and IgG4 before ...
Relationship between numbers of birch pollen and different particle sizes of the pollen antigens (Bet v) in the air in Stockholm, Sweden
airborne antigen antigen Bet v Birch pollen micronic particle pollen
2010/11/24
Micronic antigens penetrate to the lower respiratory tract and cause serious lung problems. The existence of micronic antigens in pollinosis-caused pollen has been reported. We examined the appearance...