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High Bone Mass in Mice Lacking Cx37 Due to Defective Osteoclast Differentiation
gap junctions connexin37 osteoclast
2014/11/6
Connexin (Cx) proteins are essential for cell differentiation, function and survival in all tissues with Cx43 being the most studied in bone. We now report that Cx37, another member of the connexin fa...
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2−/− mice
podosome organization bone density osteoclast functions
2014/11/6
The protein tyrosine kinase Pyk2 is highly expressed in osteoclasts, where it is primarily localized in podosomes. Deletion of Pyk2 in mice leads to mild osteopetrosis due to impairment in osteoclast ...
Oral candidosis by Candida albicans in normal and xerostomic mice
Candidiasis oral Candida albicans Xerostomia
2009/10/20
The aim of this study was to analyze the effect of sialoadenectomy on the development of oral candidosis after one or four inoculations of Candida albicans. Initially, a suspension containing 108 cell...
Localization of Bmp-4, Shh and Wnt-5a transcripts during early mice tooth development by in situ hybridization
Odontogenesis Tooth germ Wnt proteins Bone morphogenetic proteins
2009/10/19
A comparative nonisotopic in situ hybridization (ISH) analysis was carried out for the detection of Bmp-4, Shh and Wnt-5a transcripts during mice odontogenesis from initiation to cap stage. Bmp-4 was ...
Effect of Cevimeline on Radiation-Induced Salivary Gland Dysfunction and AQP5 in Submandibular Gland in Mice
Cevimeline Aquaporin5 Radiation Xerostomia
2010/12/1
The aim of this study was to clarify the effects of the muscarinic receptor agonist, cevimeline, on saliva flow and expression of aquaporin5 (AQP5) in submandibular gland after X-ray irradiation. Usin...