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Phospho-Nbs1 and Mre11 proteins which recognize DSBs co-localize with γH2AX in the nucleus after heat treatment
hyperthermia γH2AX phospho-Nbs1 Mre11 double strand break
2009/7/15
Background: Critical hyperthermia targets in cancer cells have to be clearly identified.
Method: To determine if the DNA double strand break (DSB)-recognizing proteins, phospho-Nbs1 and Mre11, co-loc...
Extracellular heat shock proteins (eHSPs) pilot exogenous antigen into cross-presentation pathway:A superguide from extracellular world to intracellular tour
Heat shock protein Hsp90 Cross-presentation Antigen presenting cell MHC class I molecule
2009/7/15
Heat shock proteins (HSPs) are intracellular chaperone, some of which function as immune adjuvants as well as danger signals for immune system when released into extracellular milieu. These HSPs, alon...
Hyperthermic sensitizers targeting heat-induced signal transductions
hyperthermic sensitivity heat apoptosis inhibitor sensitizer
2009/7/15
Hyperthermia has been used as one of the efficacious cancer therapies. To develop more efficient regimens for various malignant tumors, the attention has focused on searching for substances to sensiti...
Heat immunotherapy with heat shock protein expression by hyperthermia using magnetite nanoparticles
Heat shock proteins Hyperthermia Tumor immunity Magnetite
2009/7/15
Hyperthermia is a possible approach for cancer therapy. However, a major technical problem associated with the use of hyperthermia is the difficulty of heating the local tumor region to the intended t...