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The rate of survival for childhood cancers has increased dramatically in the last several decades, but a serious side effect of treatment is diminished fertility later in life. A potential treatment f...
Penn/Wistar Study Finds ‘Sweet Spot’ Where Tissue Stiffness Drives Cancer’s Spread
Penn/Wistar Study Sweet Spot Tissue Stiffness Cancer’s Spread
2017/3/14
In order for cancer to spread, malignant cells must break away from a tumor and through the tough netting of extracellular matrix, or ECM, that surrounds it. To fit through the holes in this net, thos...
Stiffer breast tissue in obese women promotes tumors
Stiffer breast tissue obese women promotes tumors
2015/9/9
Women who are obese have a higher risk and a worse prognosis for breast cancer, but the reasons why remain unclear. A Cornell study published this month in Science Translational Medicine explains how ...
Ectopic Prostatic and Seminal Vesicle Tissue Confusing as Metastatic Adenocarcinoma
Ectopic prostate Seminal vesicle Adenocarcinoma
2015/7/10
Ectopic prostatic tissue and seminal vesicle at pericolic fat is extremely rare. The nodules in the pericolic fat could raise a dilemma of metastatic deposits in cases of rectal adenocarcinoma. A 61 y...
Mechanism of tissue transglutaminase upregulation and its role in ovarian cancer metastasis
tissue transglutaminase TGF-beta ovarian cancer
2015/5/25
Ovarian cancer (OC) is a lethal disease due to metastasis and chemoresistance. Our laboratory previously reported that tissue transglutaminase (TG2) is overexpressed in OC and enhances OC peritoneal m...
Advances in our understanding and management of sarcomas–rare bone and soft tissue cancers
sarcomas rare bone and soft tissue cancers
2015/4/21
Bone and soft tissue sarcomas are rare, accounting for approximately 1% of all adult solid malignant tumors. Although these cancers are categorised under the same banner of ‘sarcoma’, they in fact rep...
Tissue banking and its role in clinical and biological advances in oncology
oncology biological advances
2015/4/8
Basic scientific and clinical translational progress in oncology has progressed at an exponential rate over the last 40
years. Much of this progress was germinated in the laboratory, where rigorous ...
The biopsy of bone and soft tissue sarcoma is an integral part in the management of patients with these disorders and inadequate, inappropriate or inaccurate non-representative biopsies do lead to poo...
Role of pulmonary metastasectomy in osteosarcoma and soft tissue sarcoma
pulmonary metastasectomy osteosarcoma and soft tissue sarcoma
2015/4/1
There are no randomised control trials to guide the management of patients with potentially resectable lung metastases from osteosarcoma and soft tissue sarcoma, however evidence from retrospective co...
Principles of limb sparing surgery in bone and soft tissue sarcoma
limb sparing surgery in bone soft tissue sarcoma
2015/4/1
The standard for local control of malignant bone and soft tissue tumours has been amputation. Advances in multimodality treatment have seen a shift towards preservation of the limb. Sophisticated tech...
Role of radiation therapy in the management of soft tissue sarcoma
radiation therapy soft tissue sarcoma
2015/4/1
External beam radiation therapy (pre-operative or post-operative) is an essential part of limb conservation in the management of soft tissue sarcoma of the extremity. The addition of radiation therapy...
The role of radiology in assessing bone and soft tissue sarcomas encompasses the initial detection and diagnosis of the lesion, staging the lesion both locally and systemically, guiding biopsy of the ...
Cancer clinical trials are research studies that test whether new or modified approaches to
the prevention, diagnosis or treatment of cancer are safe and effective. Some trials may also
explore as...
Tissue Carcinoembryonic Antigen, Calcium, Copper and Iron Levels in Cancerous Lung Patients
Calcium Copper Iron Human CEA protein Immunohistochemistry Lung neoplasms
2013/12/6
Background and objective The expression of various trace elements and markers in lung cancer is controversial. The aim of this study is to evaluate the presence of calcium (Ca), copper (Cu), iron (Fe)...
Neoadjuvant Chemotherapy with Ifosfamide,Cisplatin,Adriamycin and Mitomycin (IMAP) for High risk Adult Soft Tissue Sarcomas
Soft tissue sarcoma neoadjuvant surgery chemotherapy
2009/12/16
To define efficacy of pre-operative chemotherapy in down staging of advanced non-round cell soft tissue sarcomas. From Sep 2002 to Dec 2005, 70 patients were treated by Ifosfamid, MESNA, cisplatin, ad...