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氯吡格雷是使用最广泛的P2Y12血小板抑制剂，然而，部分患者存在氯吡格雷抵抗。2020年美国心脏病学杂志（JACC）子刊发表了一项研究提出了ABCD-GENE评分量表的构建。ABCD-GENE评分量表纳入包括年龄、身体质量指数(BMI)、肾功能、糖尿病病史在内的临床因素和CYP2C19基因型，以更精确的识别氯吡格雷药效学反应较低的人群。
汕头大学医学院药理学精品课程 gene polymorphism and drug and disease[1]
汕头大学 医学院 药理学 精品课程 gene polymorphism and drug and disease 1
2013/11/7
汕头大学医学院药理学精品课程 gene polymorphism and drug and disease[1]。
Mutations at C-terminal domain of pbp5 gene among high level ampicillin resistant isolates of E.faecium in Iran
Enterococcus faecium Ampicillin resistance Penicillin binding protein Nosocomial infections
2009/12/15
Background and the purpose of the study: The low affinity penicillin-binding protein (PBP) 5 of Enterococcus faecium is responsible for intrinsic resistance to beta-lactam antibiotics. This study was ...
Reactivated gene shrinks tumors, Massachusetts Institute of Technology study finds
gene p53 cancer drugs
2007/1/29
January 24, 2007，Many cancers arise due to defects in genes that normally suppress tumor growth. Now, for the first time, MIT researchers have shown that re-activating one of those genes in mice can c...
Gene Therapy: Opportunities for Pharmacy in the 21st Century
Gene Therapy Opportunities Pharmacy 21st Century
2016/3/10
Throughout the history of the profession, pharmacy has adopted technologies which have eventually become recognized responsibilities of the pharmacist. Genetic technologies, which to date, have primar...