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Mechanism-Based Inhibitors of Deoxythymidine Synthesis as Neoplastic Agents
Mechanism-Based Inhibitors Deoxythymidine Synthesis Neoplastic Agents
2016/3/10
5-Fluorouracil and methotrexate are antimetabolites widely used in the treatment of neoplastic disease. They act by inactivating the two enzymes involved in the biosynthesis of the pyrimidine nucleoti...