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Fluoride is ubiquitous in the environment. Fluoride are contained in air, soil, water, plants and animals. Human, therefore, intakes fluoride from air, drinking water and foods throughout the life. Th...
Inorganic arsenicals (iAs) are metabolized and excreted mainly in urine as dimethylarsinic acid (DMAV). Glutathione (GSH) plays an important role in the metabolism of iAs. In rat bile, the major metab...
Genetic disorders of copper metabolism are reviewed, particularly in Menkes disease and Wilson's disease. The responsible genes for Menkes disease and Wilson's disease are ATP7A and ATP7B, respectivel...
Obesity has become prevalent as a result of changes in our eating habit. We examined the effect of 20% restricted diet (80% diet) on lipid metabolism and mineral status of spontaneously obese rats (Mi...
We evaluated zinc concentrations in patients with hepatitis C virus (HCV)-positive chronic liver disease and correlated them with the clinical profiles of the patients. 11 healthy subjects also were i...
Zinc is essential for the growth of the human and animals. Bone growth retardation is a common finding in various conditions associated with zinc deficiency, suggesting a physiologic role of zinc in t...
Selenium (Se) is an essential trace element and toxicant for mammals. In human, Se is supplied by various kinds of food. Selenomethionine (SeMet), the Se analog of methionine (Met), is the major chemi...
We examined the effect of vitamin B6 deficiency on glyoxylate metabolism and hepatic alanine: glyoxylate aminotransferase (AGT) activity in rats with normal or high glyoxylate intake. Male rats were...
Muscarinic cholinergic receptor activation provokes cGMP formation in parotid acinar cells. We investigated the involvement of Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) in...
The present model can be applied to test complex hypotheses during exercise involving the integration and control of metabolic processes at various organizational levels (cellular to tissue) in indivi...
The inference, analysis and integration of networks of genes and products are fundamental goals of post-genomic research. Over the past few years several data- and knowledge-driven computational appro...
Changes in phosphorylation state and glucose uptake only significantly affect the initial phase of the glycolytic response to ischemia, while glycogen breakdown exerts control over glycolysis during t...

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