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Relationship between fluoride and Bone Metabolism:Focusing on Serum Ionic Fluoride Concentrations
Fluoride Skeletal fluorosis Osteoporosis Serum ionic fluoride concetration
2009/3/23
Fluoride is ubiquitous in the environment. Fluoride are contained in air, soil, water, plants and animals. Human, therefore, intakes fluoride from air, drinking water and foods throughout the life. Th...
The Role of Glutathione in the Metabolism and Detoxification of Trivalent Arsenicals.
arsenic metabolism arsenic-glutathione complex
2009/3/23
Inorganic arsenicals (iAs) are metabolized and excreted mainly in urine as dimethylarsinic acid (DMAV). Glutathione (GSH) plays an important role in the metabolism of iAs. In rat bile, the major metab...
Copper Metabolism and Copper Transport Disorders
Menkes disease occipital horn disease Wilson's disease ATP7A ATP7B copper
2009/3/16
Genetic disorders of copper metabolism are reviewed, particularly in Menkes disease and Wilson's disease. The responsible genes for Menkes disease and Wilson's disease are ATP7A and ATP7B, respectivel...
Effect of Dietary Restriction on Improvement of Lipid Metabolism and on Mineral Status in Spontaneously Obese Rat (Minko Rat) with Abnormal Lipid Metabolism
obesity restricted diet lipid metabolism mineral
2009/3/16
Obesity has become prevalent as a result of changes in our eating habit. We examined the effect of 20% restricted diet (80% diet) on lipid metabolism and mineral status of spontaneously obese rats (Mi...
Clinical Significance of Zinc Metabolism in C-viral Chronic Liver disease
Zinc concentration Zinc supplementation chronic hepatitis C hepatocellular carcinoma liver cirrhosis
2009/3/16
We evaluated zinc concentrations in patients with hepatitis C virus (HCV)-positive chronic liver disease and correlated them with the clinical profiles of the patients. 11 healthy subjects also were i...
Role of Zinc in Bone Metabolism and Preventive Effect on Bone Disorder
zinc bone formation bone resorption osteoporosis
2009/3/16
Zinc is essential for the growth of the human and animals. Bone growth retardation is a common finding in various conditions associated with zinc deficiency, suggesting a physiologic role of zinc in t...
Study on Detoxification and Utilization of Selenomethionine：A Role of Cystathionine γ-lyase in Selenomethionine Metabolism
selenium selenomethionine cystathionine γ-lyase metabolism methylation detoxification
2009/3/16
Selenium (Se) is an essential trace element and toxicant for mammals. In human, Se is supplied by various kinds of food. Selenomethionine (SeMet), the Se analog of methionine (Met), is the major chemi...
Effect of vitamin B6 deficiency on glyoxylate metabolism in rats with or without glyoxylate overload
vitamin B6 glyoxylate metabolism glyoxylate overload
2009/3/2
We examined the effect of vitamin B6 deficiency on glyoxylate metabolism and hepatic alanine: glyoxylate aminotransferase (AGT) activity in rats with normal or high glyoxylate intake. Male rats were...
Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase in cGMP metabolism in rabbit parotid acinar cells
Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase cGMP metabolism rabbit parotid acinar cells
2009/3/2
Muscarinic cholinergic receptor activation provokes cGMP formation in parotid acinar cells. We investigated the involvement of Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) in...
A computational model of skeletal muscle metabolism linking cellular adaptations induced by altered loading states to metabolic responses during exercise
skeletal muscle metabolism cellular adaptations metabolic responses
2010/2/26
The present model can be applied to test complex hypotheses during exercise involving the integration and control of metabolic processes at various organizational levels (cellular to tissue) in indivi...
Review of "Gene Regulation and Metabolism" edited by Julio Collado-Vides and Ralf Hofestädt
Gene Regulation and Metabolism Julio Collado-Vides Ralf Hofestä dt
2010/2/26
The inference, analysis and integration of networks of genes and products are fundamental goals of post-genomic research. Over the past few years several data- and knowledge-driven computational appro...
Computational studies of the effects of myocardial blood flow reductions on cardiac metabolism
myocardial blood flow cardiac metabolism
2010/3/1
Changes in phosphorylation state and glucose uptake only significantly affect the initial phase of the glycolytic response to ischemia, while glycogen breakdown exerts control over glycolysis during t...