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近日,山东大学公共卫生学院孙强教授和山东省肿瘤医院王家林研究员团队在医学Top期刊Cancer上发表了题为“Long-term Effectiveness of One-time Endoscopic Screening for Esophageal Cancer: A Community-Based Study in Rural China”的研究论文,定量化揭示了食管癌内镜筛查效果的显著性和持...
Simulation-based parameter estimation offers a powerful means of estimating parameters in complex stochastic models. We illustrate the application of these ideas in the setting of a natural history mo...
Background: We present a simulation model that predicts U.S. breast cancer mortality trends from 1975 to 2000 and quantifi es the impact of screening mammography and adjuvant therapy on these trends. ...
Invasive breast cancer is commonly staged as local, regional or distant disease. We present a stochastic model of the natural history of invasive breast cancer that quantifies (1) the relative rate th...
Background. With the increasing interest in post-GWAS research which represents a transition from genome-wide association discovery to analysis of functional mechanisms, attention has been lately focu...
The influence of DNA cis-regulatory elements on a gene's expression has been intensively studied. However, little is known about expressions driven by trans-acting DNA hotspots. DNA hotspots harborin...
We present an applied study in cancer genomics for integrating data and inferences from laboratory experiments on cancer cell lines with observational data obtained from human breast cancer studies. T...
Because their services are based decisively on the collection, analysis and exchange of clinical information or knowledge, within and across organizational boundaries, knowledge management has excepti...
In this paper, we extend the previously proposed MRH methods(Bouman et al.2005, 2007) into the hierarchical multiresolution hazard setting (HMRH), to accommodate the case of separate hazard rate funct...
The aim of this work is to propose models to study the toxic effect of different concentrations of some standard mutagens in different colon cancer cell lines. We find estimates and, by means of an in...
One of the most important physical phenomena in our universe is the existence of electromagnetic waves. They consist of electric and magnetic fields rapidly reversing in direction and propagating t...
An unusually intractable policy problem of environmental pollution and toxic waste disposal is how to deal with the risk of chemically induced cancer. Many features of this issue make this policy ta...
This paper investigates the effect of health insurance on health and the use of health services by exploiting a change in insurance status that occurs for most Americans at age 65; that is, eligibilit...

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