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DNA双链断裂（double strand break，DSB）是极为严重的DNA损伤形式。如果不对其进行修复或修复错误及修复不及时，可导致基因组突变和更大范围的结构重排，引起细胞癌变或者基因组不稳定性相关疾病等。
近日，中南大学湘雅医院临床药理研究所张伟教授团队的原创性成果“Cancer Nanobombs Delivering Artoxplatin with a Polyigniter Bearing Hydrophobic Ferrocene Units Upregulate PD-L1 Expression and Stimulate Stronger Anticancer Immunity”和“E...
Circulation Research | 周菁课题组与合作者发现基质刚度通过盘状结构域受体1（DDR1）的“液-液”相分离机制抑制Hippo通路（图）
高血压 糖尿病 高脂血症
2023/8/11
动脉硬化在慢性肾病患者中普遍存在，其发生率和严重程度与心血管危险因素密切相关，包括年龄、高血压、糖尿病和高脂血症等。细胞外基质（ECM）刚度可影响血管平滑肌细胞（VSMCs）的表型和行为。ECM硬化会导致VSMC过度增殖、迁移，并从收缩表型向合成表型转化。然而，细胞是如何感知ECM刚度的改变，并将力学信号转化成生物学信号，这一问题仍有待深入研究。
2022年11年10日，北京大学基础医学院生理学与病理生理学系孔炜教授与孙金鹏教授合作在国际知名心血管杂志《Circulation Research》上在线发表了题为“Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification”的研究论文，揭示了细胞外基质蛋白Nidogen-2作为LGR4的一种新...
相分离（phase separation）指溶液中生物大分子（蛋白，DNA以及RNA等）在适当的温度、pH及盐浓度下，达到一定浓度后形成浓相和稀相（或者多相）的过程。近年的研究表明相分离是驱动细胞内无膜细胞器形成的重要机制之一，并且参与调控基因转录、信号传导、染色质组装和蛋白质降解等重要生物学过程。蛋白质是细胞内相分离液滴的主要组分之一，近几年来越来越多的蛋白被证明可发生相分离，其相分离过程的属性...
越来越多的研究表明，在多种肿瘤组织内存在一小部分致瘤能力特别强、分化程度极低并具有干细胞的自我更新及多向分化特性的细胞，称为“肿瘤干细胞（Cancer Stem Cells, CSCs）”。醛脱氢酶1A1（Aldehyde dehydrogenas 1A1，ALDH1A1）是乳腺肿瘤干细胞（Breast Cancer Stem Cells，BCSCs）的重要生物标志物之一。研究发现，ALDH1A...
2021年11月18日，浙江大学生命科学研究院沈立课题组在Nucleic Acids Research杂志上在线发表了题为“Relaxed 3D genome conformation facilitates the pluripotent to totipotent-like state transition in embryonic stem cells”的研究论文，通过三维基因组测序等一系列...
浙江大学生命科学研究院2021年10月1日冯新华和金建平实验室联合在Cancer Research发文揭示AMBRA1调控TGF-β促癌信号的分子机制与功能（图）
冯新华 金建平 细胞增殖 胚胎发育
2022/10/25
2021年10月1日，浙江大学生命科学研究院冯新华实验室和金建平实验室联合在Cancer Research（癌症研究）发表题为“AMBRA1 promotes TGF-β signaling via non-proteolytic polyubiquitylation of Smad4”的研究论文。转化生长因子β (Transforming Growth Factor-β, TGF-β) 在细胞增...
近日，医学部许兴智教授团队在《Nucleic Acids Research》（影响因子16.971）发表了题为“PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair”的原创研究成果。报道揭...
Breaking Down Barriers to Pharmacy Graduate Education: The Report of the 2017-2018 Research and Graduate Affairs Committee
Breaking Pharmacy Graduate
2018/11/22
The 2017-2018 Research and Graduate Affairs Committee (RGAC) was given three charges aimed at helping academic pharmacy address barriers that must be overcome by both students and schools to attract, ...
Outcomes of Student-Driven, Faculty-Mentored Research and Impact on Postgraduate Training and Career Selection
Outcomes Student-Driven Faculty-Mentored
2018/11/22
Objective. To evaluate scholarly deliverables from student-driven research and explore the impact on postgraduate training placement rates, pharmacy faculty appointments and lifetime publications.
Me...
Publication Rates of Social and Administrative Sciences Pharmacy Faculty in Non-Research Intensive Pharmacy Schools
Publication Rates Social Administrative
2018/11/22
Objective. To assess the level of publication rates from 2011 through 2015 by Social and Administrative Sciences (SAS) faculty at non-research intensive pharmacy schools.
Methods. The Web of Science ...
What consent model is ethically justifiable in cancer population research?
Harm epidemiological studies the data connection
2017/2/22
The important role that explicit informed consent plays in the conduct of research cannot be denied. Inhumane medical research has prompted over many decades the articulation of guidelines, legislatio...
Research needs for assessing iodine intake, iodine status, and the effects of maternal iodine supplementation
clinical trials iodine deficiency iodine excess neurobehavioral development prenatal supplementation
2018/12/14
The Office of Dietary Supplements of the NIH convened 3 workshops on iodine nutrition in Rockville, Maryland, in 2014. The purpose of the current article is to summarize and briefly discuss a list of ...
Adherence to the cancer prevention recommendations of the World Cancer Research Fund/American Institute for Cancer Research and mortality: a census-linked cohort
WCRF/AICR recommendations lifestyle prevention mortality cancer
2018/12/14
Background: Modifiable lifestyle factors linked to cancer offer great potential for prevention. Previous studies suggest an association between adherence to recommendations on healthy lifestyle and ca...