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非酒精性脂肪性肝病（NAFLD）是全球发病率最高的慢性肝病，目前仍缺乏有效的治疗手段。NAFLD包括单纯性脂肪肝和非酒精性脂肪性肝炎（NASH），后者是一种更为严重的代谢性肝病，可以增加肝细胞癌的发生率。
Construction of Recombinant Bacmid Containing M2e-Ctxb and Producing the Fusion Protein in Insect Cell Lines
Influenza Vaccines Baculovirus Cholera Toxin Subunit B
2015/10/10
Background:: Sequence variations in glycoproteins of influenza virus surface impel us to design new candidate vaccines yearly. Ectodomain of influenza M2 protein is a surface and highly conserved prot...
Effect of Pentoxifylline Administration on Mast Cell Numbers and Degranulation in a Diabetic and Normoglycemic rat Model Wound Healing
Pentoxifylline Mast cells Diabetes Mellitus Wound Healing
2015/9/28
Background: Wound healing is a complicated and integrated process. Researches in the molecular level on human and animal models have indicated several molecular changes related to the effect of diabet...
A GENETIC STUDY OF IRANIAN POPULATIONS: RED CELL ENZYMES
Red cell enzymes phosphoglucomutase
2009/12/29
A total of 1695 blood samples collected from ten ethnically distinct populations of Iran (Turks and Kurds of Rezaieh, Lurs, Aabolis, Baluchis, Turks and Kurds of Shrvan, Zoroastrians, Tehranis, and Ke...
Screening of prognostic factors using multiplex RT-PCR technique on different leukemic cell lines
Multiplex RT-PCR T-ALL oncogene leukemia cell
2009/12/18
Background: Leukemia is one of the most common pediatric malignancies. T-cell Acute Lymphoblastic Leukemia (T-ALL) accounts for 15% of hematopoetic cancers. It has been well understood that identifica...
The Effects of Sodium Selenite on the Antioxidative Defence Mechanism of Human Hepatoma G2 Cell
Hepatoma G2 Sodium selenite Glutathione peroxidase Catalase Superoxide dismutase
2009/6/30
Human cells that live in biological harmony can become cancerous. As they do so, they engage in anaerobic respiration, undergo rapid cell growth and division according to nonmitotic rules, and importa...
Analysis of Cell-Free Fetal DNA from Maternal Plasma and Serum Using a Conventional Multiplex PCR:Factors Influencing Success
Noninvasive prenatal diagnosis maternal plasma maternal serum fetal gender determination conventional multiplex PCR
2009/6/23
Recent technology enables the use of cell-free fetal DNA in maternal plasma and serum for noninvasive prenatal genetic diagnosis. This study was designed to evaluate factors most likely to influence t...
Recognition of T Cell Epitopes Unique to Cha o 2, the Major Allergen in Japanese Cypress Pollen, in Allergic Patients Cross-Reactive to Japanese Cedar and Japanese Cypress Pollen
Cha o 2 cross-reactivity Cry j 2 pollinosis T cell epitope
2010/11/16
Background: Pollens from species of the Cupressaceae family are one of the most important causes of respiratory allergies worldwide. Many patients with pollinosis have specific IgE to both allergens f...
Dendritic Cells Bearing HLA-G Inhibit T-Cell Activation in Type 1 Diabetes
Dendritic cell HLA-G IFN-β (Interferon β)
2010/4/2
HLA-G is normally expressed on human trophoblast cells. It is a non-classical MHC molecule class I b. The role of HLA-G in diabetic type 1 is not known.We investigated the role of IFN-β in induction H...
Gene Expression Profiling of Human Mast Cell Subtypes: An In Silico Study
carboxypeptidase chymase human mast cells microarray transcriptome
2010/11/18
The MC lineage seems to be far from the granulocyte lineages including basophils. CMA1-high MCs (MCTC) and CMA1-low MCs (MCT) can be regarded as differentiated MC subtypes. As such, importance of data...
Stimulatory effect of cytochalasin D on antigen-induced phospholipase D activation in a murine mast cell model (RBL-2H3)
cytochalasin intracellular signal transduction mast cells phospholipase D
2010/11/29
To investigate the possible involvement of cytoskeletal components in antigen (Ag)-mediated activation of phospholipase D (PLD) in rat basophilic leukemia (RBL-2H3) cells, the effects of cytochalasin ...