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非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝脏疾病之一，NAFLD包括单纯性脂肪肝和非酒精性脂肪性肝炎（NASH），后者是一种更为严重的代谢性肝病，可以增加肝细胞癌的发生率。目前，NAFLD发病的病理生理机制仍未完全阐明，临床上仍缺乏有效的治疗手段。因此，深入研究NAFLD的发病机制成为肝脏领域和代谢领域的研究热点。
Multi-photon evanescent wave (MPEW) excited lanthanidedoped upconverting nanoparticles (UCNPs) for fast single particles tracking and live cell membrane imaging
biomedical optical imaging biomembranes cellular biophysics doping multiphoton processes nanomedicine nanoparticles optical tracking rare earth metals MPEW
2016/12/2
We propose a novel multi-photon evanescent wave (MPEW) excitation modality for upconverting nanoparticles (UCNPs) based microscopy. Experimental results show this new imaging method for UCNPs is nonsc...
Status of p53 and p27KIP1 in Iranian Patients With Oral Squamous Cell Carcinoma
Survival Squamous Cell Carcinoma Tumor Suppressor Protein p53
2015/11/9
Background: Alterations in p53 and p27KIP1 have been documented as important events in the carcinogenesis of various cancers, but their prognostic role in oral squamous cell carcinoma (OSCC) remains c...
CIS REGULATORY MODULE DISCOVERY IN TH1 CELL DEVELOPMENT
TH1 cell development STAT4 ChIP-on-chip ChIP-Seq
2015/5/26
Immune response enables the body to resist foreign invasions. The Inflammatory response is an important aspect in the immune response which is articulated by elements such as cytokines, APC, T-cell an...
The Regulatory Role Of Matrix Metalloproteinases In T Cell Activation
T cell activation MMP9 Matrix Metalloproteinases
2015/5/25
Introduction: Matrix metalloproteinases (MMPs) are known for their role in extracellular matrix remodeling, but their role in regulating intracellular immune cell function is unknown. We reported that...
DIFFERENTIAL ROLE OF PI-3KINASE p85 (α & β) REGULATORY SUBUNITS IN MAST CELL DEVELOPMENT
Cell cycle -- Regulation Enzymes
2015/5/25
Stem cell factor (SCF) mediated c-Kit signaling, and downstream activation of Phosphatidylinositol-3 Kinase (PI-3K) is critical for multiple biological effects mediated by mast cells. Mast cells expre...
ERK1 AND ERK2 IN HEMATOPOIESIS, MAST CELL FUNCTION, AND THE MANAGEMENT OF NF1-ASSOCIATED LEUKEMIA AND TUMORS
hematopoiesis neurofibroma leukemia
2015/5/25
Neurofibromatosis type 1 is a genetic disease that results from either heritable or spontaneous autosomal dominant mutations in the NF1 gene, which encodes a protein serving, at least in part, to acce...
THE ROLE OF CERAMIDES IN CIGARETTE SMOKE-INDUCED ALVEOLAR CELL DEATH
The complex pathogenesis emphysema involves disappearance
2015/5/25
The complex pathogenesis of emphysema involves disappearance of alveolar structures, in part attributed to alveolar cell apoptosis. The mechanism by which cigarette smoke (CS) induces alveolar cell ap...
Mechanisms of translational regulation in the pancreatic β cell stress response
Diabetes Islet ER stress Pdx1
2015/5/22
The islet beta cell is unique in its ability to synthesize and secrete insulin for use in the body. A number of factors including proinflammatory cytokines, free fatty acids, and islet amyloid are kno...
Bone cell-independent benefits of raloxifene on the skeleton: A novel mechanism for improving bone material properties
mechanical testing raloxifene toughness water bone loss
2014/12/4
Raloxifene is an FDA approved agent used to treat bone loss and decrease fracture risk. In clinical trials and animal studies, raloxifene reduces fracture risk and improves bone mechanical properties,...
Targeting acute phosphatase PTEN inhibition and investigation of a novel combination treatment with Schwann cell transplantation to promote spinal cord injury repair in rats
PTEN mTOR Schwann cells transplantation neuroprotection
2015/5/21
Human traumatic spinal cord injuries (SCI) are primarily incomplete contusion or compression injuries at the cervical spinal level, causing immediate local tissue damage and a range of potential funct...
CMV Amplifies T-cell Redeployment to Acute Exercise Independently of HSV-1 Serostatus
CYTOMEGALOVIRUS HERPESVIRUS IMMUNESYSTEM PHYSICALACTIVITY LYMPHOCYTE
2017/5/18
Latent cytomegalovirus (CMV) infection has been shown to alter the lymphocyte response to acute aerobic exercise, likely due to the corresponding increase in exercise-responsive memory CD8+ T cells. I...
Eccentric Exercise Increases Satellite Cell Content in Type II Muscle Fibers
MUSCLE STEM CELLS DLK PCNA
2017/7/14
Introduction: Satellite cells (SCs) are of key importance in skeletal muscle tissue growth, repair, and regeneration. A single bout of high-force eccentric exercise has been demonstrated to increase m...
Diclofenac inhibits Kv1.3 and Kir2.1 expressions in human macrophages and affects the membrane potential and foam cell formation
离子通道 膜电位 巨噬细胞 双氯酚酸 细胞分化
2012/8/20
目的分研究双氯芬酸对人巨噬细胞电压依赖性钾通道Kv1.3、内向整流钾通道Kir2.1表达的影响及意义。方法以健康人外周血单核细胞源性巨噬细胞对象，采用Real-time RT-PCR及Western blot技术研究双氯芬酸对Kv1.3和Kir2.1表达的影响；电压敏感染料膜电位标测技术分析膜电位的变化，并用酶荧光化学法检测摄取氧化修饰低密度脂蛋白（OxLDL）的巨噬细胞内胆固醇酯（CE）的构成比...
Comparison of Proliferation,Senescence and Differentiation into Skeletal Cell Lineages of Murine Bone Marrow-Derived and Amniotic Fluid Mesenchymal Stem Cells
Amniotic fluid Bone marrow Mesenchymal stem cells Proliferation Differentiation
2015/9/21
Background: While mesenchymal stem cells (MSCs) have been isolated from multiple tissue sources, the differences existed between the cells from different tissues have still remained to be clarified. T...