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Novel Cinnamoylated Flavoalkaloids Identified in Tea with Acetylcholinesterase Inhibition Effect
flflavoalkaloids cinnamoylated epicatechins Camellia sinensis acetylcholinesterase inhibitor
2023/4/20
3-O-Cinnamoylepicatechin (1) was synthesized along with four flflavoalkaloids, (−)-6-(5‴S)-N-ethyl-2-pyrrolidinone- 3-O-cinnamoylepicatechin (2), (−)-6-(5‴R)-N-ethyl-2-pyrrolid...
Lysine biofortification in rice by modulating feedback inhibition of aspartate kinase and dihydrodipicolinate synthase
rice Lysine aspartate kinase dihydrodipicolinate synthase
2023/7/20
Lysine is the main limiting essential amino acid (EAA) in the rice seeds, which is a major energy and nutrition source for humans and livestock. In higher plants, the rate-limiting steps in lysine bio...
Structural Basis for the Inhibition of SARS-CoV-2 Main Protease by Antineoplastic Drug Carmofur
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of...
Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion
Inhibition SARS-CoV-2 Pan-Coronavirus Fusion Inhibitor Targeting High Capacity Mediate Membrane Fusion
2020/6/12
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. To develop specific anti-coronavirus therapeuti...
Inhibition Efficiency in Highly Proficient Bilinguals and Simultaneous Interpreters: Evidence from Language Switching and Stroop Tasks
Bilingualism Language control Stroop task
2017/8/25
The present behavioral study aimed to examine the impact of language control expertise on two domain-general control processes, i.e. active inhibition of competing representations and overcoming of in...
Inhibition of sweet chemosensory receptors alters insulin responses during glucose ingestion in healthy adults: a randomized crossover interventional study
sweet taste receptors lactisole glucose intolerance insulin saccharin artificial sweeteners OGTT modeling analysis
2018/11/13
Background: Glucose is a natural ligand for sweet taste receptors (STRs) that are expressed on the tongue and in the gastrointestinal tract. Whether STRs directly contribute to the regulation of gluco...
Effects of Nitric Oxide Synthase Inhibition on Fiber-Type Composition, Mitochondrial Biogenesis,and SIRT1 Expression in Rat Skeletal Muscle
Mitochondrial biogenesis muscle fiber composition nitric oxide nitric oxide synthase silent information regulator of transcription
2016/1/9
It was hypothesized that nitric oxide synthases (NOS) regulated SIRT1 expression and lead to a corresponding changes of contractile and metabolic properties in skeletal muscle. The purpose of the pres...
Influence of Thermal and Pressure Treatments on Inhibition of Potato Tuber Sprouting
high pressure treatments heat treatments individual and combined treatments potato sprouts sprouting onset
2015/12/30
The effect of short duration thermal treatments (60 and 65°C for 1 min) and low intensity high pressure treatments
(15 and 30 MPa for 10 min) on the sprouting of potato tubers was applied individual...
Coordination of actions, visual perception and inhibition in non-human and human primate development
non-human and human actions visual perception
2015/7/30
The originality of Langer's approach to cognitive
development (Langer, 1980, 1986) lies in the study of
the pragmatic components (actions, object manipulations) of protologicomathematical and protop...
Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-alpha in the Rat
cyclooxygenase-2 COX-2 COX-1 prostaglandin E2 neuroinflammation blood-brain barrier ischemia stroke matrix metalloproteinase MMP-3 MMP-9 gelatinase B stromelysin-1 oxidative stress indomethacin cyclooxygenase-1 glutathione free radicals MRI
2015/7/29
Increased permeability of the blood-brain barrier (BBB) is important in neurological disorders. Neuroinflammation is associated with increased BBB breakdown and brain injury. Tumor necrosis factor-alp...
On the origin of the cumulative semantic inhibition effect
cumulative semantic inhibition effect
2015/7/29
We report an extension of the cumulative semantic inhibition effect found by Howard, Nickels, Coltheart, and Cole-Virtue (2006). Using more sensitive statistical analyses, we found a significant varia...
On the origin of the cumulative semantic inhibition effect
origin cumulative semantic inhibition effect
2015/7/28
We report an extension of the cumulative semantic inhibition effect found by Howard, Nickels, Coltheart, and Cole-Virtue (2006). Using more sensitive statistical analyses, we found a significant varia...
Cyclooxygenase inhibition in ischemic brain injury.
cyclooxygenase-2 ischemia stroke cerebral ischemia neuroinflammation excitotoxicity
2015/7/28
Neuroinflammation is one of the key pathological events involved in the progression of brain damage caused by cerebral ischemia. Metabolism of arachidonic acid through cyclooxygenase (COX) enzymes is ...
Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
MAPK DNA fragmentation apoptosis Bax
2015/6/24
Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after reaching the metaphase II stage, exposed to further in vitro culture. Aged oocytes remaining at the metaphas...
Loss Aversion and Inhibition in Dynamical Models of Multialternative Choice
Loss Aversion Dynamical Models Multialternative Choice
2015/6/19
The roles of loss aversion and inhibition among alternatives are examined in models of the similarity, compromise, and attraction effects that arise in choices among 3 alternatives differing on 2 attr...