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观察ω-3多不饱和脂肪酸（ω-3 PUFAs）防治结肠癌患者奥沙利铂联合卡培他滨（XELOX）方案化疗所致的周围神经毒性的有效性，为防治化疗所致周围神经毒性提供临床依据。［方法］ 采用随机、双盲、安慰剂对照研究，将符合纳入标准73例接受XELOX方案化疗的结肠癌患者随机分为治疗组（ω-3 PUFAs+化疗）37例和对照组（安慰剂+化疗）36例。各组均以21d为1个疗程，共治疗6个疗程。观察并分析两...
ω-3 PUFAs在调节结直肠癌发生发展中的研究进展
ω- 3PUFAs 结直肠癌 肿瘤微环境
2020/2/11
ω-3多不饱和脂肪酸是一类具有生物活性的多不饱和脂肪酸，对结直肠癌发生发展具有抑制作用。ω-3多不饱和脂肪酸首先改变膜流动性影响细胞功能，其次影响细胞信号转导通路中重要蛋白的活性并且调节肿瘤微环境中炎症介质和免疫细胞的功能和活性，另外改变肿瘤转移过程中的几种重要分子，从抑制细胞过度增殖，促进凋亡，提高抗肿瘤免疫和抑制肿瘤转移几个方面对结直肠癌起抑制作用。
ω-3 and ω-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases
lipid metabolism long-chain polyunsaturated fatty acid retinopathy of prematurity diabetic retinopathy age-related macular degeneration
2018/11/14
Neovascular eye diseases, including retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration, threaten the visual health of children and adults. Current treatment options...
Variability in the cardiometabolic effects of ω-3 long-chain PUFAs: background diet, timing, and genetics
Variability cardiometabolic ω-3 long-chain genetics
2018/11/13
Omega-3 long-chain PUFAs (LC-PUFAs) have received considerable attention over many years for their proposed health benefits, particularly in relation to cardiovascular disease. More recently, there ha...
Do ω-3 PUFAs affect insulin resistance in a sex-specific manner? A systematic review and meta-analysis of randomized controlled trials
adults diabetes omega-3 PUFAs DHA EPA insulin resistance insulin sensitivity
2018/12/19
Background: Evidence has suggested that omega-3 (n–3) polyunsaturated fatty acids (PUFAs) improve obesity-induced insulin resistance (IR); however, results from human intervention trials have been equ...
n–3 Long-chain PUFAs reduce respiratory morbidity caused by iron supplementation in iron-deficient South African schoolchildren: a randomized, double-blind, placebo-controlled intervention
iron morbidity n–3 long-chain polyunsaturated fatty acids randomized controlled trial supplementation schoolchildren
2018/12/24
Background: Although iron supplementation in malaria-free areas mostly reduces infectious morbidity, it can sometimes increase morbidity from infections as a result of the dependence of pathogenic mic...