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哮喘是儿童最常见的慢性呼吸道疾病，近年来，其发病率呈快速上升的趋势，国内1990-2010年儿童哮喘的发病率从1.09%增至3.02%，20年增加了2.8倍。目前上海市儿童的哮喘发病率已超过8%，成为国内发病率最高的城市，严重影响着儿童的生长发育及身心健康。哮喘是一种是由遗传、环境和表观遗传学因素等相互作用而引起的一种免疫炎症性疾病。表观遗传学是不依赖于DNA序列变化而由染色质改变产生的可稳定遗传...
周玉峰团队在《Journal of Allergy and Clinical Immunology》首次揭示环状RNA在过敏性皮炎和银屑病中的功能及调控机制（图）
周玉峰团队 环状RNA 银屑病 过敏性皮炎
2023/4/14
过敏性皮炎（atopic dermatitis，AD）也称特应性皮炎，是一种慢性复发性的皮肤炎症性疾病，发病率在儿童中高达20-30%，成人为3-10%。主要临床表现为皮肤屏障功能受损、瘙痒和慢性皮肤炎症。AD的病因复杂，病情迁延不愈，极大地影响了患者的生活质量。近年来的研究表明除遗传因素外，环境和表观遗传学因素也在一定程度上影响着AD的发病过程。此外，“过敏性进程”理论揭示婴幼儿期的AD有可能随...
Food safety and label claims for hazelnut allergy traces:evaluation of two PCR assays
amplification declaration food allergy hazelnut
2015/10/9
The molecular techniques (C-PCR, RT-PCR) in the detection and quantification of allergic substances of hazelnut in various categories of food commodities, e.g. breakfast cereals, chocolates and biscui...
Evidence of an Infectious Asthma Phenotype: Chlamydia Driven Allergy and Airway Hyperresponsiveness in Pediatric Asthma
allergy asthma atopy chlamydia hyperresponsivness
2015/1/28
Asthma is the most common chronic respiratory disease affecting young children and adults all over the world. An estimated 34.1 million Americans have reported asthma in their lifetime and the disease...
INVESTIGATING THE RELATION BETWEEN PREVALENCE OF ASTHMATIC ALLERGY WITH THE CHARACTERISTICS OF THE ENVIRONMENT USING ASSOCIATION RULE MINING
Spatial Association Rule Mining Environmental Characteristics Asthmatic Allergy Air Pollution Apriori
2014/12/1
The prevalence of allergic diseases has highly increased in recent decades due to contamination of the environment with the allergy stimuli. A common treat is identifying the allergy stimulus and, the...
Potentials of probiotics in the treatment of food allergy – a review
lactobacillus food proteins allergen immunomodulation peanut
2014/7/10
Food allergy is an adverse immune response to some proteins in some foods. Probiotic, health promoting bacteria have gained much importance because of their innumerable benefits, particularly in the t...
Background: Screening patients for latex allergy prior to surgery is an important but intensive procedure. The appropriate testing strategy for diagnosing latex (Hevea brasiliensis) allergy involves i...
POLLEN SPECTRUM AND RISK OF POLLEN ALLERGY IN CENTRAL SPAIN
aerobiology atmospheric pollen meteorology pollen calendar
2010/12/22
The present work analyses the airborne pollen dynamic of the atmosphere of Toledo (central Spain), a World Heritage Site and an important tourist city receiving over 2 millions of visitors every year.
GENETIC ASPECT OF VENOM ALLERGY:ASSOCIATION WITH HLA CLASS I AND CLASS II ANTIGENS
genetic human leukocyte antigens hymenoptera
2010/12/22
Stings from bees and wasps can cause systemic allergic reactions in sensitized patients. However, the mystery of why some cases develop allergic reactions while others do not, remains poorly understoo...
An 18-year Follow-up of Allergy Development Related to Nasal Metachromatic Cell Findings During Infancy
allergy cohort study metachromatic cells nasal epithelium prediction
2010/11/12
The cumulative number of subjects with allergy was 46, probable allergy 5, and no allergy 13. Detected MCinfancy predicted allergy with high accuracy (31/33), but negative MCinfancy findings did not e...
Lipocalin-Type Prostaglandin D Synthase and Egg White Cystatin React with IgE Antibodies from Children with Egg Allergy
cystatin food allergy hen's egg white LC-MS/MS lipocalin-type prostaglandin D synthase
2010/11/12
Background: Ovalbumin, ovomucoid, ovotransferrin, lysozyme, and ovomucin are known to be major allergens found in egg white. Egg white protein is composed of over 30 proteins; many of which have neith...
IL-1 and Allergy
Allergy Asthma Dermatitis IL-1
2010/11/12
IL-1 is a well-characterized proinflammatory cytokine that is involved in host defense and autoimmune diseases. IL-1 can promote activation of T cells, including Th1 cells, Th2 cells and Th17 cells, a...
Rush Specific Oral Tolerance Induction in School-Age Children with Severe Egg Allergy: One Year Follow Up
egg allergy food allergy immunotherapy oral tolerance rush
2010/11/12
Background: At present, the only treatment for food allergy is to avoid the allergy-causing food. Some trials of specific oral tolerance induction (SOTI) have been carried out, but the rate of toleran...
Although the current standard care for patients with food allergy is based on avoidance of the trigger foods with hope of possible gain of tolerance, increasing number of studies have shown that oral ...
As the key molecule of type-I-hypersensitivity, IgE provides specificity for the allergen and links it to the allergic effector functions. Antibodies are secreted by plasma cells and their precursors,...