搜索结果: 1-15 共查到“知识库 理学 genome”相关记录59条 . 查询时间(0.075 秒)
卵母细胞和早期胚胎异常是造成女性不孕及试管婴儿反复失败的重要原因。已有研究证实，遗传因素在卵母细胞和早期胚胎异常中发挥重要作用。既往研究主要集中于大家系及近亲家系患者，且致病突变主要遗传自父母，展现为显性遗传或隐性遗传模式。然而，新发突变（De novo mutations，DNMs）在卵母细胞和早期胚胎异常中发挥怎样的作用尚不清楚。
2023年03月27日，上海市免疫学研究所陈磊研究员团队在Genome Research上发表了题为“Simultaneous profiling of host expression and microbial abundance by spatial meta-transcriptome sequencing”的研究论文。该研究首次开发了空间宏转录组测序及一体化的生物信息分析技术SMT(Spa...
Genome-wide identification of NF-YA gene family in cotton and the positive role of GhNF-YA10 and GhNF-YA23 in salt tolerance
全基因组分析 雷蒙德氏棉 亚洲棉 海岛棉 陆地棉
2024/5/17
本研究基于全基因组分析，在雷蒙德氏棉、亚洲棉、海岛棉和陆地棉基因组中分别鉴定得到16、16、31和29个NF-YA基因。通过进化树分析将NF-YA基因分为4个亚组。结构分析表明NF-YA基因在棉属进化过程中相对保守。荧光定量显示GhNF-YAs可能通过ABA和 MeJA的调控通路响应盐和干旱。VIGS沉默GhNF-YA10和GhNF-YA23的表达，能显著降低棉花对盐的抗性，表明这两个基...
浙江大学生命科学研究院2021年1月7日周琦实验室在Nature、Genome Res和GigaScience同日发表三篇论文系统阐述动物性染色体多样性（图）
周琦 动物性染色体 性染色体演化
2022/10/26
性染色体从遗传上决定了两性之间截然不同的生殖器官发育命运和成年个体的外形差异，展现出许多与常染色体截然不同的基因组特点和演化模式，一直是生物学家追踪的研究对象。经典的性染色体演化理论认为，性染色体通常起源于一对古老的常染色体，为了防止性别决定基因在性染色体之间发生交换，性别决定座位之间通常不发生同源重组。这种重组抑制的代价是雄性特异的Y染色体，或者雌性特异的W染色体发生不可逆的退化，丢失了绝大多数...
Investigations on Genetic Architecture of Hairy Loci in Dairy Cattle by Using Single and Whole Genome Regression Approaches
Genome Wide Association Analyses Discordant Sib Pair Analyses Whole Genome Regression Analyses
2016/7/27
Development of body hair is an important physiological and cellular process that leads to better adaption in tropical environments for dairy cattle. Various studies suggested a major gene and, more re...
Complete Mitochondrial Genome Sequences of Chinese Indigenous Sheep with Different Tail Types and an Analysis of Phylogenetic Evolution in Domestic Sheep
Mitochondrial DNA Mitogenome Sheep Phylogenetic Mitochondrial Control Region
2016/5/20
China has a long history of sheep (Ovis aries [O. aries]) breeding and an abundance of sheep genetic resources. Knowledge of the complete O. aries mitogenome should facilitate the study of the evoluti...
Genome-wide polymorphisms show unexpected targets of natural selection
population genomics natural selection
2015/12/11
Natural selection can act on all the expressed genes of an individual, leaving signatures of genetic differeniation or diversity at many loci across the genome. New power to assay these genome-wide ef...
Whole-Genome Positive Selection and Habitat-Driven Evolution in a Shallow and a Deep-Sea Urchin
positive selection dN/dS
2015/12/11
Comparisons of genomic sequence between divergent species can provide insight into the action of natural
selection across many distinct classes of proteins. Here, we examine the extent of positive se...
Transcriptome sequencing reveals both neutral and adaptive genome dynamics in a marine invader
adaptation invasive species natural selection contemporary evolution
2015/12/11
Species invasions cause significant ecological and economic damage, and genetic information is important to understanding and managing invasive species. In the ocean,
many invasive species have...
Our personal genome, which is the map of our DNA, is our ultimate source of identity,
which should be given our highest concern for security. The primary approach used for
securing any highly sensit...
Genome-wide Association Study to Identify Quantitative Trait Loci for Meat and Carcass Quality Traits in Berkshire
Berkshire Quantitative Trait Loci Single Nucleotide Polymorphism Meat Quality
2016/5/19
Meat and carcass quality attributes are of crucial importance influencing consumer preference and profitability in the pork industry. A set of 400 Berkshire pigs were collected from Dasan breeding far...
A Genome-wide Scan for Selective Sweeps in Racing Horses
Single Nucleotide Polymorphism Racehorse Selective Sweep Quantitative Trait Loci
2016/5/19
Using next-generation sequencing, we conducted a genome-wide scan of selective sweeps associated with selection toward genetic improvement in Thoroughbreds. We investigated potential phenotypic conseq...
Stories and Challenges of Genome Wide Association Studies in Livestock — A Review
QTL Livestock Genome-wide Association
2016/5/18
Undoubtedly livestock is one of the major contributors to the economy of any country. The economic value of livestock includes meat, dairy products, fiber, fertilizer etc. Understanding and identifyin...
Whole Genome Association Study to Detect Single Nucleotide Polymorphisms for Behavior in Sapsaree Dog (Canis familiaris)
Sapsaree Single Nucleotide Polymorphism Behavior Heritability Genome-wide Association
2016/5/18
The purpose of this study was to characterize genetic architecture of behavior patterns in Sapsaree dogs. The breed population (n = 8,256) has been constructed since 1990 over 12 generations and manag...
Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds
Single Nucleotide Polymorphism Estimated Breeding Value
2016/5/18
Thoroughbred, a relatively recent horse breed, is best known for its use in horse racing. Although myostatin (MSTN) variants have been reported to be highly associated with horse racing performance, t...