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Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation
STAT6VT transgenic Atopic Dermatitis
2015/5/25
Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease with a lifetime prevalence of 10-20% in children and 1-3% in adults, worldwide. In the past three decades, prevalence of the dis...
Resolution of Inflammation Induces Osteoblast Function and Regulates the Wnt Signaling Pathway
inflammation osteoblast
2014/12/4
Objective Inflammation in the bone microenvironment stimulates osteoclast differentiation, resulting in uncoupling of resorption and formation. Mechanisms contributing to the inhibition of osteoblast ...
Alteration of endogenous corticosteroids and catecholamines in allergen-induced eosinophilic inflammation in Brown Norway rats
airway inflammation asthma Brown Norway rat endogenous corticosteroid metabolic cage urinary catecholamine excretion urinary 11-hydroxycorticosteroid excretion
2010/11/29
Although various types of stress activate a pituitary adrenal response, the alteration of endogenous corticosteroids and catecholamines during asthma remains unclear. The aim of this study was to asse...
Airway inflammation and repair in asthma
airway remodeling asthma eosinophils inflammation mast cells T cells
2010/11/25
Asthma is a disease of usually reversible airways obstruction that has prominent inflammation of the mucosa as an underlying feature. It is a disease of varying severity, with some individuals sufferi...
Mechanisms of eosinophilic inflammation in the mucosa of the nasal cavity and paranasal sinus
allergic rhinitis eosinophil eotaxin
2010/11/25
More than one mechanism contributes to persistent increases in eosinophils in the nasal cavity and paranasal sinus. The levels of eotaxin in lavage samples obtained after antigen challenge showed stro...
Improved Case of Bronchial Asthma by Re-administration of Pranlukast from Montelukast: Evaluation of Eosinophilic Inflammation in the Peripheral Airway
asthma eosinophil cationic protein (ECP) eotaxin induced sputum Pranlukast
2010/11/22
Following the re-administration of Pranlukast, the clinical symptoms disappeared within a few days and pulmonary function improved within 4 weeks. Eosinophils in the induced sputum almost completely d...