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近日，北京大学第三医院心血管内科徐明教授团队在代谢顶级期刊 《自然·代谢》 （Nature Metabolism）在线发表了题为《TGR5抑制脂肪酸摄取改善糖尿病心肌病》（Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy）的研究成果，揭示了糖尿病心肌病心脏脂代谢调节新机制，架起了胆汁酸代谢与心脏脂代谢之...
Impairment of lysophospholipid metabolism in obesity: altered plasma profile and desensitization to the modulatory properties of n–3 polyunsaturated fatty acids in a randomized controlled trial
DHA EPA nflammation men and women randomized controlled trial risk factors
2018/12/3
Background: To date, most studies on the anti-inflammatory effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in humans have used a mixture of the 2 fatty acids in various forms and...
Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on gastrointestinal metabolism of ingested glucose
glucose surgery tracers weight loss intestine metabolism diabetes
2018/11/23
Background: Data from studies conducted in animal models suggest that intestinal glucose uptake and metabolism are upregulated after Roux-en-Y gastric bypass (RYGB) surgery, which contributes to a wei...
A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism
conjugated linoleic fatty acid (CLA) body composition energetic metabolism
2015/9/24
Conjugated linoleic acid (CLA) is highly found in fats from ruminants and it appears to favorably modify the body composition and cardiometabolic risk factors. The capacity of CLA to reduce the body f...
Effects of Dietary Acid Load on Exercise Metabolism and Anaerobic Exercise Performance
Renal acid load alkaline diet substrate oxidation respiratory exchange ratio
2015/8/28
Dietary acid load, quantified as the potential renal acid load
(PRAL) of the diet, affects systemic pH and acid-base regulation. In a previous cross-sectional study, we reported that a low
dietary...
Effect of supplementation with chokeberry juice on the inflammatory status and markers of iron metabolism in rowers
Exercise Rowers Supplementation Chokeberry Iron Interleukin
2015/7/29
The aim of this study was to analyze the effect of supplementation with chokeberry (Aronia melanocarpa) juice on the levels of pro-inflammatory cytokines, hepcidin, and selected markers of iron metabo...
Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation
Lipoproteins Quercetin Flavonoids Inflammation Exercise
2015/7/29
We proposed that mice supplemented with quercetin, a class of flavonoids known to have antioxidant and anti-inflammatory properties, will have profound effects on the pathophysiology of atherosclerosi...
The effect of carbohydrate and marine peptide hydrolysate co-ingestion on endurance exercise metabolism and performance
Marine peptide Hydrolyzed protein Exercise metabolism
2015/7/27
The purpose of this study was to examine the efficacy of introducing a fish protein hydrolysate (PEP) concurrently with carbohydrate (CHO) and whey protein (PRO) on endurance exercise metabolism and p...
Recent Advances in Iron Metabolism: Relevance for Health, Exercise, and Performance
IRON HEMOGLOBIN MUSCLE HEPCIDIN MYOGLOBIN
2017/4/19
ABSTRACT: Iron is necessary for physiological processes essential for athletic performance, such as oxygen transport, energy production, and cell division. However, an excess of “free” iron is toxic b...
Acute Effects of Exercise and Calorie Restriction on Triglyceride Metabolism in Women
HYPOCALORIC DIET TRIGLYCERIDE, HYPOTRIGLYCERIDEMIA
2017/7/14
Purpose: The mechanisms by which exercise reduces fasting plasma triglyceride (TG) concentrations in women and the effect of negative energy balance independent of muscular contraction are not known.
...
Effect of Zinc Deficiency on Zinc and Carbohydrate Metabolism in Genetically Diabetic (C57BL/Ksj Db+/Db+) and Non-Diabetic Original Strain (C57BL/Ksj) Mice
Strain zinc depletion diabetic mice (C57BL/KsJdb+/db+) nondiabetic mice (C57BL/KsJ)
2009/6/23
Our aim was to investigate the effect of low dietary zinc intake on zinc and carbohydrate metabolism in type II diabetes. Male, 4–5-week-old, genetically diabetic (C57B/LKsJdb+/db+) and nondiabe...
Zinc contribution to the regulation of glucose disposal, lipid metabolism and striated muscle contractions
zinc homeostasis zinc deficiency insulin sensitivity lipids striated muscle
2009/4/2
Zinc is the second, after iron, most abundant trace metal in the human body. In living systems zinc performs three categories of functions- catalytic, structural and regulatory. Zinc homeostasis is ...
Oxidative Stress and Homocysteine Metabolism Following Coronary Artery Bypass Grafting by On-pump and Off-pump Techniques
Oxidative stress Homocyteine On-pump CABG Off-pump CABG
2010/4/8
Background: It is well documented that coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) causes ischemia and oxidative stress of the whole body. To compare the effect of on – pu...
Effects of Glucocorticoid on Bone Metabolism Markers and Bone Mineral Density in Rats
Glucocorticoid Osteoporosis Bone metabolism markers BMD
2010/2/8
Statement of Problem: Glucocorticoid-induced osteoporosis is characterized by a decrease in osteoblast numbers and a marked impairment of new bone formation. Purpose: The ain of present study was to e...